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Design and analysis of a class of redundant collaborative manipulators with 2-dimension large rotational

Xiaodong JIN, Yuefa FANG, Dan ZHANG, Xueling LUO

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 66-80 doi: 10.1007/s11465-019-0570-x

Abstract: The parallel spindle heads with high rotational capability are demanded in the area of multi-axis machineThis paper focuses on designing a class of 2R1T (R: Rotation; T: Translation) parallel spindle headsA class of redundant 2R1T parallel spindle heads is obtained by connecting the redundant limbs with thekinematics and the orientation workspace as well as the decoupling characteristics of this type of 2R1Tparallel spindle heads are analyzed.

Keywords： parallel mechanism     redundant mechanism     large rotational angles     machine tools     2R1T spindle head     collaborative    

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Basic consideration of research strategies for head and neck cancer

Johnson, Scott Coman, Alan R. Clough

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 339-353 doi: 10.1007/s11684-012-0213-7

Abstract:

Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomicalaims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head

Keywords： clinical management     head and neck cancer     prevention and early detection     research strategies     risk factors    

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Non-iterative parameter estimation of the 2R-1Cmodel suitable for low-cost embedded hardware Article

Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 3,   Pages 476-490 doi: 10.1631/FITEE.1900112

Abstract: Parameter estimation of the 2R-1C model is usually performed using iterative methods that require high-performanceThe 2R-1C model parameters are subsequently calculated from the real and imaginary parts of the measuredComparative analysis conducted on the impedance data of the 2R-1C model obtained in both simulation andMoreover, we compared the QINIPE and the complex nonlinear least squares (CNLS) estimation of the 2R-1C model parameters.

Keywords： 2R-1C model     Embedded systems     Parameter estimation     Non-iterative methods     Quadratic interpolation    

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A multi-scale model for CO

R. WEI, V. RUDOLPH, C. T. WEI, Y. QIN

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11705-009-0138-0

Abstract: This paper presents a multi-scale model to simulate the multicomponent gas diffusion and flow in bulk coals for CO sequestration enhanced coalbed methane recovery. The model is developed based on a bi-dispersed structure model by assuming that coal consists of microporous micro-particles, meso/macro-pores and open microfractures. The bi-disperse diffusion theory and the Maxwell-Stefan approach were incorporated in the model, providing an improved simulation of the CH —CO /CH —N counter diffusion dynamics. In the model, the counter diffusion process is numerically coupled with the flow of the mixture gases occurring within macro-pores or fractures in coal so as to account for the interaction between diffusion and flow in gas transport through coals. The model was validated by both experimental data from literature and our CO flush tests, and shows an excellent agreement with the experiments. The results reveal that the gas diffusivities, in particular the micro-pore diffusivities are strongly concentration-dependent.

Keywords： multi-scale model     gas transport     coal     coalbed methane     CO2 sequestration    

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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 130-136 doi: 10.15302/J-FASE-2014013

Abstract: this study, using real-time quantitative RT-PCR, we investigated the expression pattern of and its head-to-headmarked decrease of both and mRNA ( <0.05); however, progesterone, transforming growth factor-β 1These results indicate that the head-to-head genes of and exhibit similar expression in chicken follicles

Keywords： chicken     Vps36     Ckap2     mRNA     follicle    

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Screening of potential aquatic probiotics from the major microflora of guppies (

Aparna BALAKRISHNA, T. R. KEERTHI

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 163-173 doi: 10.1007/s11705-012-1283-4

Abstract: Among the resulting isolates, two were gram-positive cocci, namely MBTU-PB2 and MBTU-PB3 and belong toThe other two were gram-negative rods, namely MBTU-PB1 and MBTU-PB4, of the genera and , respectively

Keywords： aquaculture     normal flora     immunomodulatory effect     probiotic     antagonistic principle     bacteriocin like inhibitory substances    

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Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 1,   Pages 1-18 doi: 10.1007/s11709-012-0141-2

Abstract: This paper presents a comprehensive review of modeling of alkali-silica reaction (ASR) in concrete. Such modeling is essential for investigating the chemical expansion mechanism and the subsequent influence on the mechanical aspects of the material. The concept of ASR and the mechanism of expansion are first outlined, and the state-of-the-art of modeling for ASR, the focus of the paper, is then presented in detail. The modeling includes theoretical approaches, meso- and macroscopic models for ASR analysis. The theoretical approaches dealt with the chemical reaction mechanism and were used for predicting pessimum size of aggregate. Mesoscopic models have attempted to explain the mechanism of mechanical deterioration of ASR-affected concrete at material scale. The macroscopic models, chemo-mechanical coupling models, have been generally developed by combining the chemical reaction kinetics with linear or nonlinear mechanical constitutive, and were applied to reproduce and predict the long-term behavior of structures suffering from ASR. Finally, a conclusion and discussion of the modeling are given.

Keywords： alkali-silica reaction (ASR)     modeling     concrete     mesoscopic     macroscopic    

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Optimization of cellulase production using

Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 443-452 doi: 10.1007/s11705-012-1225-1

Abstract: The potential of for cellulase production using pineapple waste as substrate has been investigated. A maximum cellulase activity of 9.23 U/mL is obtained under the optimum experimental conditions: pH (5.5), temperature (37.5°C), initial substrate concentration (3%), inoculum concentration (6.6 × 10 ?CFU/mL), and culture time (6 days). Box-Behnken design (BBD) statistical tool and genetic algorithm (GA) are used to optimize the process parameters. The BBD study of linear and quadratic interactive effects of experimental variables on the desired response of cellulase activity showed that the second order polynomial is significant ( = 0.9414). The experimental cellulase activity under the optimal conditions identified by the BBD is 9.23 U/mL and that by GA is 6.98 U/mL. This result indicates that the BBD model gives better result than GA in the present case.

Keywords： cellulase     pineapple waste     Trichoderma reesei     Box-Behnken design     genetic algorithm    

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A novel flow electrode capacitive deionization device with spindle-shaped desalting chamber

Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11783-024-1800-y

Abstract:

● A spindle-shaped influent chamber was designed and equipped in

Keywords： Spindle-shaped chamber     Desalination performance     Flow electrode capacitive deionization    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,More than 60% of T-ALL patients carry NOTCH1 gene mutations, leading to abnormal expression ofWe found that chidamide, an HDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primarycells including an anti-NOTCH1 activity.form of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasome

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Techno-economic evaluation of a biogas-based oxidative coupling of methane process for ethylene production

Alberto T. Penteado, Mijin Kim, Hamid R. Godini, Erik Esche, Jens-Uwe Repke

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 4,   Pages 598-618 doi: 10.1007/s11705-018-1752-5

Abstract:

This contribution is a preliminary techno-economic assessment of a biogas-based oxidative coupling of methane (OCM) process. Biogas is frequently utilized as a renewable energy source within small scale combined heat and power plants or as a natural gas substitute. The activation of methane also enables its utilization as a feedstock to produce chemicals. In this sense, the OCM process allows for the direct conversion of methane into ethylene, which is a major building block for the chemical and polymer industries. Biogas resulting from the anaerobic digestion of vinasse, a liquid effluent from bioethanol industry, is treated for contaminant removal and its methane content is converted into ethylene, which is then purified as the main product. The biogas cleaning process is assessed based on literature data, while an experimentally validated simulation model is used to assess the OCM process. A techno-economic evaluation is then performed through a Monte Carlo simulation, wherein uncertain parameters take random values between reasonable bounds. The net present value results positive in 74% of the cases, indicating that the project is profitable under a wide range of scenarios. Some performance improvement opportunities have been identified and highlighted to guide future studies in the topic.

Keywords： biogas conversion     ethylene production     oxidative coupling of methane     feasibility study    

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Treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA)

VECITIS, Hyunwoong PARK, Jie CHENG, Brian T. MADER, Michael R. HOFFMANN

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 129-151 doi: 10.1007/s11783-009-0022-7

Abstract: Fluorochemicals (FCs) are oxidatively recalcitrant, environmentally persistent, and resistant to most conventional treatment technologies. FCs have unique physiochemical properties derived from fluorine which is the most electronegative element. Perfluorooctanesulfonate (PFOS), and perfluorooctanoate (PFOA) have been detected globally in the hydrosphere, atmosphere and biosphere. Reducing treatment technologies such as reverses osmosis, nano-filtration and activated carbon can? remove ?FCs ?from ?water. ?However,? incineration ?of the concentrated waste is required for complete FC destruction. Recently, a number of alternative technologies for FC decomposition have been reported. The FC degradation technologies span a wide range of chemical processes including direct photolysis, photocatalytic oxidation, photochemical oxidation, photochemical reduction, thermally-induced reduction, and sonochemical pyrolysis. This paper reviews these FC degradation technologies in terms of kinetics, mechanism, energetic cost, and applicability. The optimal PFOS/PFOA treatment method is strongly dependent upon the FC concentration, background organic and metal concentration, and available degradation time.

Keywords： fluorochemical (FC) degradation technologies     perfluoroctanesulfonate (PFOS)     perfluorooctanoate     (PFOA)     oxidation     reduction     photolysis     thermolysis     review    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expression3-kinase (PI-3K), AKT-2, glucose transporter-4 (GLUT-4), p38 mitogen-activated protein kinase (p38MAPKThe glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independentThe mRNA expression of two signal proteins PI-3K and AKT-2 decreased and the other two signal proteins, GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associatedIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsSurvival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-MeierWe found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 374-379 doi: 10.1007/s11684-008-0072-4

Abstract: Expression of DNA methyltransferase 1 (DNMT1), which plays an important role on aberrantly methylatedIn this study, the eukaryotic vector pshRNA-DNMT1 was constructed and transfected into T24 cells.inhibitory rates of DNMT1 mRNA levels in T24 cells were 28.44%, 52.48%, 70.91%, respectively.The growth inhibition rates of pshRNA-DNMT1 at the 24th, 48th and 72nd hour after transfection of pshRNA-DNMT1points ( < 0.01); 24, 48 and 72 hours after T24 cells were transfected by pshRNA-DNMT1, the apoptosis
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Title Author Date Type Operation

Design and analysis of a class of redundant collaborative manipulators with 2-dimension large rotational

Xiaodong JIN, Yuefa FANG, Dan ZHANG, Xueling LUO

Journal Article

Basic consideration of research strategies for head and neck cancer

Johnson, Scott Coman, Alan R. Clough

Journal Article

Non-iterative parameter estimation of the 2R-1Cmodel suitable for low-cost embedded hardware

Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ

Journal Article

A multi-scale model for CO

R. WEI, V. RUDOLPH, C. T. WEI, Y. QIN

Journal Article

Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Journal Article

Screening of potential aquatic probiotics from the major microflora of guppies (

Aparna BALAKRISHNA, T. R. KEERTHI

Journal Article

Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

Journal Article

Optimization of cellulase production using

Saravanan P, Muthuvelayudham R, Rajesh Kannan R, Viruthagiri T

Journal Article

A novel flow electrode capacitive deionization device with spindle-shaped desalting chamber

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Techno-economic evaluation of a biogas-based oxidative coupling of methane process for ethylene production

Alberto T. Penteado, Mijin Kim, Hamid R. Godini, Erik Esche, Jens-Uwe Repke

Journal Article

Treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA)

VECITIS, Hyunwoong PARK, Jie CHENG, Brian T. MADER, Michael R. HOFFMANN

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Journal Article